Help and support Frequently asked questions Treatment FAQs Why did my first botulinum toxin injections not work? When first starting botulinum treatment it can often take several rounds to get relief. Finding the best spots for injection and the right dosage can take time. To understand why your injections are not working, and if changes are needed, you must discuss this with your injector. It can be helpful to document the following information to help your discussion: percentage of improvement after the injection how long the benefit lasted after the injection side effects after the injection what has improved and what has not improved after the injection